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bio-experimental-design-randomization-blocking - Design valid biological experiments with randomization and blocking

Identifies experimental units, plans randomization and blocking, selects factorial or hierarchical layouts, and aligns analysis with the experimental design.

Tags

Updated: 2026-10-02

Capabilities

Typical Inputs

Typical Outputs

What this skill does

  • Identify experimental units
  • Distinguish observational units
  • Plan treatment randomization
  • Randomize processing order
  • Choose blocking layouts
  • Design factorial experiments
  • Structure split-plot errors
  • Model nested variation
  • Avoid pseudoreplication
  • Specify random effects

Inputs

  • Experimental units
  • Treatment factors
  • Nuisance factors
  • Run-order constraints
  • Hierarchical measurements

Outputs

  • Experimental-unit definition
  • Treatment assignments
  • Run-order assignments
  • Design layout
  • Analysis model structure

Requirements

  • R environment
  • designit 0.5+
  • lme4 1.1-35+
  • lmerTest 3.1+
  • pwr 1.3+
  • Installed package documentation

Source

  • Spec: SKILL.md

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biological experiment design
randomization
blocking
experimental units
pseudoreplication
factorial design
split-plot design
nested design
mixed-effects models
Identify experimental units
Distinguish observational units
Plan treatment randomization
Randomize processing order
Experimental units
Treatment factors
Nuisance factors
Experimental-unit definition
Treatment assignments
Run-order assignments