depmap - Cancer Dependency Map
Query DepMap for cancer cell line gene dependency scores, drug sensitivity data, and gene effect profiles to validate targets and find synthetic lethality.
Tags
Updated: 2026-09-24Capabilities
Typical Inputs
Typical Outputs
What this skill does
- Query gene dependency scores
- Download DepMap data files
- Load CRISPR gene effect matrix
- Identify selective dependencies
- Perform biomarker analysis
- Analyze co-essentiality between genes
Inputs
- Gene symbols
- DepMap dataset CSV files
- Cell line sample metadata
- Cancer types or lineages
Outputs
- Gene dependency API JSON response
- Selective dependent cell line data
- Biomarker statistical analysis results
- Co-essential gene correlation rankings
- Downloaded DepMap CSV data files
Requirements
- Python 3
- Python packages (requests, pandas, numpy, scipy)
- Internet access for DepMap API