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lifesciences-crispr - CRISPR Essentiality & Synthetic Lethality Validation

Validates synthetic lethality claims and gene essentiality from CRISPR screens using BioGRID ORCS data.

Tags

Updated: 2026-09-19
crisprsynthetic-lethalitybiogrid-orcsgene-essentialitylife-sciences

Capabilities

Resolve gene identifiersQuery essential CRISPR screensRetrieve screen annotationsExtract dependency scores

Typical Inputs

Gene symbols or identifiersBioGRID screen IDsCell line names

Typical Outputs

Essentiality scoresScreen annotationsCell line dependency comparisons

What this skill does

  • Resolve gene identifiers
  • Query essential CRISPR screens
  • Retrieve screen annotations
  • Extract dependency scores
  • Compare cross-cell line essentiality

Inputs

  • Gene symbols or identifiers
  • BioGRID screen IDs
  • Cell line names

Outputs

  • Essentiality scores
  • Screen annotations
  • Cell line dependency comparisons
  • JSON screen data files

Requirements

  • BioGRID API key
  • cURL tool
  • jq tool
  • BioGRID ORCS API access

Source

  • Spec: SKILL.md

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