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maic-methodology - MAIC Methodology Guidance

Methodological guidance for conducting rigorous Matching-Adjusted Indirect Comparisons

Tags

Updated: 2026-05-11

Capabilities

Typical Inputs

Typical Outputs

What this skill does

  • select covariates
  • interpret weights
  • check ESS
  • decide anchored approach
  • review MAIC code
  • estimate weights
  • run anchored MAIC
  • run unanchored MAIC
  • check covariate balance

Inputs

  • IPD data
  • AgD targets
  • covariate names
  • pseudo IPD
  • treatment labels

Outputs

  • treatment effect estimate
  • weight summary
  • covariate balance table
  • confidence interval
  • effective sample size

Requirements

  • R environment
  • maicplus package
  • NICE DSU TSD 18

Source

  • Spec: SKILL.md
methodology
statistics
MAIC
indirect comparison
health economics
select covariates
interpret weights
check ESS
decide anchored approach
IPD data
AgD targets
covariate names
treatment effect estimate
weight summary
covariate balance table