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tooluniverse-pharmacogenomics - Analyze pharmacogenomic drug-gene evidence

Resolves PGx entities, retrieves CPIC and PharmGKB evidence, annotates variants and alleles, checks FDA labeling, and generates evidence-graded recommendations.

Tags

Updated: 2026-10-15

Capabilities

Typical Inputs

Typical Outputs

What this skill does

  • Resolve genes, drugs, and variants
  • Identify CPIC gene-drug pairs
  • Retrieve dosing recommendations
  • Annotate alleles and variants
  • Check FDA biomarker labeling
  • Generate evidence-graded reports

Inputs

  • Gene symbols
  • Drug names
  • Variant identifiers
  • Metabolizer phenotypes
  • Pharmacogenomic database records
  • ChEMBL identifiers

Outputs

  • Resolved entity identifiers
  • Gene-drug evidence summaries
  • Dosing recommendations
  • Allele and variant annotations
  • FDA labeling status
  • Evidence-graded clinical reports

Requirements

  • ToolUniverse tools
  • Bash access for Python computation
  • Access to CPIC and PharmGKB data

Source

  • Spec: SKILL.md
pharmacogenomics
drug-gene interactions
CPIC
PharmGKB
variant annotation
clinical dosing
Resolve genes, drugs, and variants
Identify CPIC gene-drug pairs
Retrieve dosing recommendations
Annotate alleles and variants
Gene symbols
Drug names
Variant identifiers
Resolved entity identifiers
Gene-drug evidence summaries
Dosing recommendations