tooluniverse-protein-interactions - Protein Interaction Network Analysis
Analyzes protein-protein interaction networks using STRING, BioGRID, and SASBDB through identifier mapping, network retrieval, enrichment analysis, and optional structural data lookup.
Tags
Updated: 2026-06-30Capabilities
Typical Inputs
Typical Outputs
What this skill does
- map protein identifiers
- retrieve interaction networks
- perform functional enrichment analysis
- search SAXS/SANS structural data
- query BioGRID curated interactions
- get signaling pathway interactions
- map proteins to Reactome pathways
- query drug-gene interactions
- get gene druggability categories
- get gene constraint metrics
- search clinical evidence items
- get protein function annotations
- calculate multimer binding valency
- predict coiled-coil oligomeric state
Inputs
- Protein names or UniProt IDs
- NCBI taxonomy ID
- Confidence score threshold
- BioGRID API key (optional)
- Gene symbols
Outputs
- Interaction network data with confidence scores
- Functional enrichment analysis results
- SAXS/SANS structural data entries
- Drug-gene interaction reports
- Gene constraint and essentiality metrics
Requirements
- STRING API access (no key required)
- BioGRID API key for fallback interactions
- SASBDB API access for structural data
- ToolUniverse runtime environment