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validated-link-enrichment-analysis - Assess GCF-MF link predictions with Fisher exact test

Quantifies whether high-scoring GCF-MF link predictions are enriched for experimentally validated pairs using Fisher exact test.

Tags

Updated: 2026-09-21
metabolomicsgenomicsenrichment analysisFisher exact testGCF-MF links

Capabilities

Apply score percentile thresholdsCalculate validated link proportionsPerform Fisher exact testCompare scoring strategy enrichment

Typical Inputs

Scored GCF-MF link predictionsCurated validated GCF-MF pairs

Typical Outputs

Validated link proportionsFisher exact test p-valuesEnrichment contingency tables

What this skill does

  • Apply score percentile thresholds
  • Calculate validated link proportions
  • Perform Fisher exact test
  • Compare scoring strategy enrichment

Inputs

  • Scored GCF-MF link predictions
  • Curated validated GCF-MF pairs

Outputs

  • Validated link proportions
  • Fisher exact test p-values
  • Enrichment contingency tables

Requirements

  • Curated validated reference links
  • Standardised scoring functions
  • At least 50 validated links

Source

  • Spec: SKILL.md

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