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bio-chip-seq-motif-analysis - ChIP-seq motif discovery and enrichment

Identify DNA sequence motifs enriched in ChIP-seq or ATAC-seq peaks using HOMER and MEME-ChIP

Tags

Updated: 2026-05-11
bioinformaticsChIP-seqATAC-seqmotif analysistranscription factorsgenomics

Capabilities

identify enriched motifsdiscover de novo motifsscan genome for motifscompare motifs to database

Typical Inputs

ChIP-seq peaksATAC-seq peaksgenomic sequences

Typical Outputs

discovered motifsmotif enrichment statisticsmotif annotation files

What this skill does

  • identify enriched motifs
  • discover de novo motifs
  • scan genome for motifs
  • compare motifs to database
  • create custom motifs
  • extract peak sequences
  • parse motif results
  • visualize motif logos

Inputs

  • ChIP-seq peaks
  • ATAC-seq peaks
  • genomic sequences
  • motif database
  • background regions
  • genome reference

Outputs

  • discovered motifs
  • motif enrichment statistics
  • motif annotation files
  • sequence logos
  • motif location files

Requirements

  • HOMER installed
  • MEME Suite installed
  • bedtools installed
  • conda environment
  • configured genome
  • CPU resources

Source

  • Spec: SKILL.md

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